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PROPERDIN PATHWAY
Descriptors Found:
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DeCS
Descriptor
English
:
Complement Pathway, Alternative
Descriptor
Spanish
:
Vía Alternativa del Complemento
Descriptor
Portuguese
:
Via Alternativa do Complemento
Synonyms
English
:
Alternative Complement Pathway
Properdin Pathway
Tree Number:
G12.425.255.695
Definition
English
:
Complement activation
initiated by the interaction of microbial
ANTIGENS
with
COMPLEMENT C3B
. When
COMPLEMENT FACTOR B
binds to the membrane-bound C3b,
COMPLEMENT FACTOR D
cleaves it to form alternative
C3 CONVERTASE
(C3BBB) which, stabilized by
COMPLEMENT FACTOR P
, is able to cleave multiple
COMPLEMENT C3
to form alternative C5 CONVERTASE (C3BBB3B) leading to cleavage of
COMPLEMENT C5
and the assembly of
COMPLEMENT MEMBRANE ATTACK COMPLEX.
History Note
English
:
91(79); was see under COMPLEMENT ACTIVATION 1979-90
Allowable Qualifiers
English
:
DE
drug effects
ES
ethics
GE
genetics
IM
immunology
PH
physiology
RE
radiation effects
Record Number:
3216
Unique Identifier:
D003170
Occurrence in VHL
:
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